The CDC is undergoing significant upheaval following the announcement of five high-level departures, described as retirements, that occurred on Tuesday. This follows earlier losses, totaling nearly a third of the agency’s top management in recent weeks. The departures come just as President Trump nominated Susan Monarez as the permanent CDC director. Amid growing concerns over public trust in the CDC, particularly regarding vaccine safety, Monarez will face challenges in restoring confidence while navigating potential staff reductions and organizational changes proposed by the Trump administration.