Christina Applegate Reveals MS Misdiagnosis

The actor says she is back at square one after learning her MS diagnosis was wrong.

Balanced

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Updated Oct 20, 8:12pm ET

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What happened

Christina Applegate said her doctors reversed her multiple sclerosis diagnosis after concluding that she does not have MS. She had believed she had the disease since 2021. The reassessment followed further testing, including newer technology. Applegate said an earlier review began after her doctor stopped an infusion treatment and monitored her B-cell count. She first disclosed the diagnosis after numbness and pain, then became a public advocate. MS has no single definitive test, so clinicians weigh symptoms, exams, imaging or spinal-fluid tests while ruling out similar conditions. Applegate said she remains seriously ill, still needs a wheelchair for medical visits, and feels shocked. Her doctors will soon investigate the cause.

How each side covered it

From the left

Left-leaning outlets framed the reversal as a painful loss of answers, not a recovery story. The New York Times centered Applegate’s own point that she is still sick without knowing why. The Boston Globe stressed that MS diagnosis depends on ruling out other causes, not one clear test. Rolling Stone lingered on her fear that she had misrepresented herself to the MS community.

From the right

Right-leaning outlets led with the same bleak turn, emphasizing unresolved illness over relief. The Epoch Times used Applegate’s account to show that her physical problems remain unresolved. The New York Post tied the case to misdiagnosis risks, where overlapping symptoms can lead to wrong treatment. The Washington Times focused on her feeling that she had let people down and remained in shock.

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