The San Francisco 49ers are grappling with injuries as tight end George Kittle misses a crucial game against the Seattle Seahawks. Kittle, who has been a standout performer, is dealing with a hamstring injury sustained in the previous match. Defensive end Nick Bosa, despite a hip pointer that raised questions about his fitness, is cleared to play. Meanwhile, Rams wide receiver Puka Nacua also faces injury challenges, having left a game against the Patriots but returning shortly after. These developments are significant as the 49ers look to maintain their position in the NFC.