The Philadelphia Eagles will start their title defense against the Dallas Cowboys on September 4, 2025, in an NFC East rivalry game. The matchup indicates a dynamic change for both teams; the Eagles, fresh off their Super Bowl victory, face a Texans franchise in transition. The Cowboys are looking to bounce back from a disappointing season, hoping a healthy Dak Prescott and their offseason additions will make a difference. The full NFL schedule will be unveiled on Wednesday, but this opener has already generated significant buzz.