Groundbreaking studies by teams at Stanford University and Kyushu University have uncovered the genetic mutation causing orange coloration in cats, attributed to a deletion in the ARHGAP36 gene on the X chromosome. This mutation increases gene activity in melanocytes, the cells responsible for pigment. The findings not only elucidate why orange cats are predominantly male but also open doors for further research into feline health. These studies, funded by cat lovers, mark a significant advancement in understanding feline genetics and coat coloration.